Immunotherapy in Pediatic Malignancies
Speaker: Alex Y. Huang, M.D., Ph.D.
- Theresia G. & Stuart F. Kline Family Foundation
- Chair in Pediatric Oncology Associate Professor of Pediatrics
- Patology & Biomedical Engineering Case Western Reserve University
- School of Medicine Associate Director, Pediatric Hematology-Oncology
- Fellowship Program, UH Rainbow Babies &Childeren’s Hospital
Dr. Huang received medical scientist training program at the Johns Hopkins University School of Medicine where he completed his Ph.D. thesis. After completing pediatric residency at Johns Hopkins Hospital. Dr. Huang entered the combined pediatric hematology/oncology clinical fellowship training program at Johns Hopkins Hospital and the National Cancer Institute. While a postdoctoral fellow in the NIAID, Dr. Huang received the Cancer Research Institute Postdoctoral Fellowship Award and was among the first to develop the new technique of intravital 2-photon laser scanning. In 2006, Dr. Huang joined the Case Western Reserve University School of Medicine faculty as an Assistant Professor in the Division of Pediatric Hematology / Oncology. Currently, Dr. Huang is also the director of clinical fellowship program in Pediatric Hematology / Oncology. Dr. Huang’s laboratory research program is focused on adapting intravital 2-photon laser scanning microscopy to study various aspects of in vivo immunity and pathogenesis. These efforts include investigating the role of tumor microenvironment in immune cell recruitment and tolerance induction, interplay between chronic inflammatory conditions with carcinogenesis of the gastrointestinal track, regulation of T cell receptor activation by inflammatory chemokines, and mechanisms of pathogenic lymphocyte recruitment induction in animal models of multiple sclerosis.